ビタミンのサプリメントは体に有害！？ [世界は今…]
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近年、科学の発達により、バランスのとれた食生活をせずとも人の栄養状態をコントロールできるようになりました。仕事に忙殺されたり、やせたいという過度な欲求などから、女性を中心として、日々の食事を制限し、必要とされる栄養をサプリメントを用いて摂取する傾向があります。この近年の画期的発明とも言える習慣に警鐘を鳴らす研究が一躍有名となっています。当初食事を通じて摂取することが困難なものを補う目的で開発されたサプリメントが、極端な場合では１食すべてを錠剤で置き換えるというもはや乱用に近い事態にまでなる例も少なくありませんが、本当に食事を摂らずとも同等の効果が得られるのでしょうか。The Japan Timesの記事を引用して検証していきたいと思います。
To date, we can control our nutritional state without taking balanced diet. Females in particular tend to gain nutrients necessary for maintaining daily activities by resorting to dietary supplements whereas they limit food intake, due in part to busy life like a honey-bee and due in part to their desire to become thinner. Recently, research questioned the effectiveness of the dietary supplements which might be one of the most epoch-making inventions in the present decade. Dietary supplements were initially developed with a view to supplementing nutrients which would be difficult to take: however, they are now kinda abused; i.e. some may alter whole diet with the capsules and pills. Can we enjoy the effectiveness equivalent to consuming balanced diet? I would discuss the issue featuring an article posted to The Japan Times.
Vitamins were some of the most promising medicines of the 1990s -- wonder pills that appeared to fight cancer, heart disease, stroke and other ailments.
ビタミンは体によく、同時に必要な物質であることは周知の事実です。例えばがんの原因となる酸化プロセスを抑えるための抗酸化物質であるビタミンEやビタミンCなどは健康な生活を送る上で不可欠ですが、バランスの取れた食生活をすることが困難な現代社会においてとかく不足しがちとされます。ここでサプリメントと呼ばれる錠剤が注目されるようになりました。一見して、抗酸化剤ががんや心臓病、脳卒中といった病気に効果があり、それが不足するのだから、それを補うことで問題がないように思えますが、果たしてサプリメントは食事のピンチヒッターとなりうるのでしょうか。
Laboratory tests and initial studies in people suggested that vitamin pills could play a crucial role in preventing some of the most intractable illnesses, especially in an aging population. The National Institutes of Health gave them the same treatment as top-notch pharmaceutical drugs, investing hundreds of millions of dollars in elaborate clinical trials designed to quantify their disease-fighting abilities.
試験管レベルの検討や初期の人での検証では、ビタミン剤が病気に対して一定の効果を持つことが確かめられました。しかし臨床試験の結果はこれとは異なるものでした。
Now the results from those trials are rolling in, and nearly all of them fail to show any benefit from taking vitamins and minerals.
サプリメントは効果がないかもしれないというのです。
This month, two long-term trials involving more than 50,000 participants offered fresh evidence that vitamin C, vitamin E and selenium supplements don't reduce the risk of prostate, colorectal, lung, bladder or pancreatic cancer. Other recent studies have found that over-the-counter vitamins and mineral offered no help in fighting other cancers, stroke and cardiovascular diseases.
計50000人の協力を得て実施した2つの長期の臨床試験において、ビタミンC、ビタミンE、セレンのサプリメントはどれも前立腺、結腸直腸、肺、膀胱、そして膵臓のがんのリスクを低減することができませんでした。他にも、薬局で購入できるビタミンやミネラルのサプリメントで同様の実験を行いましたが、やはりがんや脳卒中、心臓病のリスクの低下は認められなかったとのことです。ではサプリメントは何の目的でとるのでしょうか。
Research has even suggested that, in some circumstances, vitamin and mineral supplements can be unsafe.
効果がないどころか、条件によってはこれらサプリメントの使用が危険をもたらすことも示唆されたのでした。
Some physicians now advise their patients not to bother with taking the pills and to rely instead on a healthy diet to provide needed vitamins and minerals.
医師によってはサプリメントの使用を勧めない人もいるのだとか。サプリメントを常用している皆さん、要注意ですね。
"These things are ineffective, and in high doses they can cause harm," said Dr. Edgar Miller, a professor of medicine and epidemiology at Johns Hopkins University School of Medicine in Baltimore, Md. "People are unhappy with their diets, they're stressed out, and they think it will help. It's just wishful thinking."
効果がないどころか、所定の量以上を摂ると健康に害がある―これはサプリメントが薬局やインターネットで簡単に入手できることによって生じる問題です。病院で処方される薬と違って、服用量を自分で判断する必要があり、無意識に過剰量を摂っていることも多いのです。からだにいいから、と気軽に手を出しがちなサプリメントですが、脂溶性ビタミンなどは体内に蓄積され、過剰症を引き起こしやすいことは事実です。
Yet faith in vitamins runs deep. The Council for Responsible Nutrition, a Washington-based trade group, estimates that 64 percent of American adults take vitamin and mineral supplements. Despite the steady drumbeat of reports questioning their efficacy, sales have risen consistently from $5 billion in 1995 to $10 billion this year, according to Nutrition Business Journal.
それにも関わらずサプリメントは売れています。この10年で約2倍に需要が増えたそうです。
Scientists remain convinced that vitamins are essential to health. But they have puzzled over how their obvious benefits could be so elusive tin randomised controlled trials, the gold standard of medical research.
ビタミンは確かに必要です。どうやらサプリメントとしての摂り方に問題がありそうです。
"You really do need vitamin E. You really do need vitamin C. You really do need selenium," said Jeffrey Blumberg, director of the U.S, Department of Agriculture's Antioxidants Research Laboratory at Tufts University in Boston. "Without them, you die."
Blumberg and others now believe that a combination of factors -- including the versions of vitamins that were tested and the populations they were tested in -- probably doomed the studies from the start.
"In retrospect, maybe the expectations were a little bit unrealistic," said Blumberg, whose research has been funded in part by supplement makers.
Unlike observational studies, which look backward at groups of people to identify factors that are associated with a particular disease, a forward-looking randomised controlled trial has the power to show that a particular factor can prevent the disease.
どのようなサプリメントを摂ったか、それによってどのような効果があったかという追跡調査だけでなく、プラセボを用いた薬の臨床試験の手法をとり実験を行ったそうです。すると・・・。
The studies rely on thousands of participants who are randomly assigned to receive a medicine or an identical looking dummy pill. Researchers carefully track the participants so they can account for other factors that might affect health outcomes, such as age, diet and amount of physical activity. After several years, the researchers compare the number of people in each group that developed a particular disease and use statistical tools to see whether the medicine made a difference.
Vitamin A and beta carotene were the first supplements to be tested that way. In observational studies from the 1980s, researchers noticed that people who ate lots of vegetables rich in beta carotene, a precursor of vitamin A, were less likely to be diagnosed with lung cancer and other cancers compared with people who didn't. Thus, they reasoned, the vitamin supplements likely reduced the risk of lung cancer.
1980年代、ビタミンAの前駆体であるβ-カロテンを多く含む野菜を多く食べた人は食べなかった人に比べて肺がんをはじめとしたがんを患うリスクが低かったという研究があります。しかし・・・。
The thinking was, "Let's get a bunch of people who smoked for 30 years and see if it's going to be a magic bullet for them," a vice president for scientific and regulatory affairs for the Council for Responsible Nutrition, a trade association for the supplement industry. "We were all guilty of wanting to go for that home run-style randomised trial that would validate everything once and for all."
It didn't.
One trial that followed 29,000 male smokers in Finland for an average of six years found that men who took beta carotene were 18 percent more likely to be diagnosed with lung cancer and 8 percent more likely to die during the study than men who didn't.
フィンランドで平均年齢60歳の喫煙者29000人を対象とした実験によると、β-カロテンを摂取した人のほうが摂取しなかった人と比較して肺がんと診断された割合が18%高く、また死亡率も8%高いという結果が得られました。実験の諸条件はこの記事では明らかにされていませんが、1980年の実験と決定的に異なるのはβ-カロテンの摂り方です。錠剤として摂った場合、期待に反した作用が認められたわけですね。
A second trial involved 18,000 American men and women who were smokers, former smokers, or were exposed to asbestos at work. That study found that after and average of four years, lung cancer rates were 28 percent higher among those who took beta carotene and vitamin A, and their overall risk of death during the trial jumped by 17 percent.
これだけではありません。アメリカでも喫煙者、以前に喫煙していた人、そして仕事中にアスベストを吸引しているであろう計18000人の協力を得て実験を行ったところ、β-カロテンやビタミンAを摂取した層では肺がんになったリスクが対照群と比較して28%も高く、また死亡率も17%高かったそうです。
Further research revealed that beta carotene curbs the body's ability to metabolise vitamin A, which is needed to keep cancer cells in check.
後の研究で、β-カロテンはがん細胞を監視するビタミンAの代謝をコントロールすることがわかったのです。
Researchers have identified several reasons why vitamins don't lend themselves to randomised controlled trials. Chief among them is that there is no true placebo group when it comes to vitamins and minerals because everyone gets some in their diet.
"For drugs, someone either has (the impotence drug) Cialis in their system or he doesn't have Cialis," said Paul Coates, director of the National Institutes of Health Office of Dietary Supplements in Bethesda, Md. With vitamins, on the other hand, "there's a baseline exposure that needs to be taken into account, It makes the challenge of seeing an improvement more difficult." A vitamin's benefit may become apparent only if people aren't getting enough of it already.
食事を摂る関係上、どうしても雑多な因子が含まれてしまい、ビタミン剤の効能がどれほどなのか正確に知ることは非常に困難ですが、確かなのは、サプリメントは摂り方を誤まると深刻な事態を引き起こす可能性があり、できることなら毎日バランスのよい食生活を心がけ、体によいものを食べたほうがよいということですね。
Researchers plan to learn more about the role of nutrition in fighting disease.
"I'm really comfortable telling you to eat whole grains and fruits and vegetables and cut back on saturated fats," one researcher said, "even though we don't have clinical trials showing that"
(A good diet beats vitamin pills, The Japan Times, issued on 24 December, 2008)
Happy New Year！
昨年はありがとうございました！
今年もどうぞ宜しくお願い致します。
Shin.
by shin (2009-01-01 14:14)
> Shinさん
あけましておめでとうございます。
2009年がShinさんにとって実り多き年でありますように☆
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